Mebendazole

Research use only, not for human use.

A highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells.

A highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells.Parasite Infection Approved.

Immunofluorescence Cell Line:Glioblastoma multiforme (GBM) 060919 cellsConcentration:1 μM Incubation Time:24 hours Result:Disrupted microtubule structure.Immunofluorescence Cell Line:DAOY and hTERT-RPE1 cells Concentration:0, 0.1, 0.5, 0.75, and 1 μM Incubation Time:12 hours Result:Decreased GLI1 protein level and increased cleavage of caspase-3 protein level.

Animal Model:C57BL/6 mice (5-6 weeks old) implanted with GL261 glioma cells and 060919 human glioblastoma multiforme (GBM)Dosage:50 mg/kg; delivered with 50% (v/v) sesame oil and PBSAdministration:Oral gavage; beginning 5 days after tumor implantation at a daily dose of 50 mg/kg for the first 20 days of treatment then changed to 50 mg/kg for 5 days, with 2 days off, each week.Result:Increased the mean survival to 49 days compared with the 30 days of control in syngeneic GL261 mouse model.Increased the mean survival to 65 days compared with the 48 days of control in 060919 human glioblastoma multiforme (GBM) xenograft mouse model.

NSC 184849 | R 17635

Microbiology/Virology

Parasite

Tubulinα-1Achain|Tubulinβ-4Bchain

Infection

Parasite Infection

31431-39-7

295.2927

C16H13N3O3

>98% (HPLC)

DMSO: ≥ 23 mg/mL

COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3

Carbamic acid, N-(6-benzoyl-1H-benzimidazol-2-yl)-, methyl ester

(-20℃)

With Ice Pack

≥ 2 years