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Arteether
CAS No. 75887-54-6
Arteether( Artemotil | Dihydroartemisinin ethyl ether | NSC 665971 )
Catalog No. M15885 CAS No. 75887-54-6
Arteether, a new antimalarial drug.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 49 | In Stock |
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| 10MG | 78 | In Stock |
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| 25MG | 182 | In Stock |
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| 50MG | 273 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameArteether
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NoteResearch use only, not for human use.
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Brief DescriptionArteether, a new antimalarial drug.
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DescriptionArteether, a new antimalarial drug.(In Vitro):The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.(In Vivo):Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7).
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In VitroThe antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.
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In VivoArtemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7). Animal Model:Sprague-Dawley male rats (220-280 g)Dosage:25 mg/kg; 1 mL/kg body weight Administration:Intravenous injection; daily; for 7 days Result:Anorectic toxicity was observed, and that caused significant reductions in food consumption and body weight after day 2.
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SynonymsArtemotil | Dihydroartemisinin ethyl ether | NSC 665971
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PathwayAutophagy
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TargetCCR
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RecptorCCL4| CCL5| CXCL10| CXCL9
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number75887-54-6
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Formula Weight312.4
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Molecular FormulaC17H28O5
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Purity>98% (HPLC)
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SolubilitySoluble in DMSO
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SMILESC[C@H]1[C@@H](OCC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3
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Chemical Name(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dwivedi H, et al. Parasitology. 2016, 143(12):1557-68.
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