Arteether

CAS No. 75887-54-6

Arteether( Artemotil | Dihydroartemisinin ethyl ether | NSC 665971 )

Catalog No. M15885 CAS No. 75887-54-6

Arteether, a new antimalarial drug.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Arteether
  • Note
    Research use only, not for human use.
  • Brief Description
    Arteether, a new antimalarial drug.
  • Description
    Arteether, a new antimalarial drug.(In Vitro):The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.(In Vivo):Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7).
  • In Vitro
    The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin.
  • In Vivo
    Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7). Animal Model:Sprague-Dawley male rats (220-280 g)Dosage:25 mg/kg; 1 mL/kg body weight Administration:Intravenous injection; daily; for 7 days Result:Anorectic toxicity was observed, and that caused significant reductions in food consumption and body weight after day 2.
  • Synonyms
    Artemotil | Dihydroartemisinin ethyl ether | NSC 665971
  • Pathway
    Autophagy
  • Target
    CCR
  • Recptor
    CCL4| CCL5| CXCL10| CXCL9
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    75887-54-6
  • Formula Weight
    312.4
  • Molecular Formula
    C17H28O5
  • Purity
    >98% (HPLC)
  • Solubility
    Soluble in DMSO
  • SMILES
    C[C@H]1[C@@H](OCC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3
  • Chemical Name
    (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dwivedi H, et al. Parasitology. 2016, 143(12):1557-68.
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