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Aripiprazole

CAS No. 129722-12-9

Aripiprazole( OPC 31 | OPC 14597 )

Catalog No. M11199 CAS No. 129722-12-9

Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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100MG 52 In Stock
200MG 68 In Stock
500MG 93 In Stock
1G 122 In Stock
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Biological Information

  • Product Name
    Aripiprazole
  • Note
    Research use only, not for human use.
  • Brief Description
    Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
  • Description
    Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.(In Vitro):Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation.Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine.(In Vivo):Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties.
  • In Vitro
    Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation.Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine.
  • In Vivo
    Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties. Animal Model:WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam)Dosage:0, 0.3, 1, 3 mg/kg Administration:IP, 1 mL/kg, every day at 5 p.m. until the end of the experiments Result:Showed some anxiolytic properties with the 1 mg/kg dose being the most active.
  • Synonyms
    OPC 31 | OPC 14597
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT1A
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    129722-12-9
  • Formula Weight
    448.39
  • Molecular Formula
    C23H27Cl2N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 90 mg/mL (200.71 mM)
  • SMILES
    C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
  • Chemical Name
    7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nasrallah HA. Mol Psychiatry. 2008 Jan;13(1):27-35.
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