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VA-012
CAS No. 885898-58-8
VA-012( VA012 )
Catalog No. M16412 CAS No. 885898-58-8
VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameVA-012
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NoteResearch use only, not for human use.
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Brief DescriptionVA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM.
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DescriptionVA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM; shows no significant off-target activities, and low binding competition with serotonin or other orthosteric ligands; increases the anorectic effect combined with the SSRI sertraline; reduces food intake and body weight gain without causing CNS-related malaise.
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In Vitro——
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In Vivo——
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SynonymsVA012
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number885898-58-8
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Formula Weight313.4
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Molecular FormulaC21H19N3
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC=C(C=C1)CN2C=C(C3=CC=CC=C32)CNC4=CN=CC=C4
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Chemical Name1-(Phenylmethyl)-N-3-pyridinyl-1H-indole-3-methanamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. García Cárceles J, et al. J Med Chem. 2017 Nov 8. doi: 10.1021/acs.jmedchem.7b00994.
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