
Argatroban
CAS No. 74863-84-6
Argatroban( MCI-9038 )
Catalog No. M15853 CAS No. 74863-84-6
Argatroban is a direct, selective thrombin inhibitor.
Purity : >98% (HPLC)






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Biological Information
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Product NameArgatroban
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NoteResearch use only, not for human use.
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Brief DescriptionArgatroban is a direct, selective thrombin inhibitor.
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DescriptionArgatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and prevent the formation of thrombi. Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be obtained prior to administering argatroban.
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In VitroArgatroban (MD-805) may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Administration (0.5 to 2 micrograms/kg/min) of Argatroban (MD-805) is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries. Argatroban (MD-805), as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban.
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In Vivo——
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SynonymsMCI-9038
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PathwayAutophagy
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TargetThrombin
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RecptorThrombin
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number74863-84-6
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Formula Weight508.63
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Molecular FormulaC23H36N6O5S
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Purity>98% (HPLC)
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SolubilityEthanol: 6 mg/mL (11.79 mM); DMSO: 9 mg/mL (17.69 mM)
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SMILESC[C@@H]1CCN([C@H](C1)C(=O)O)C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kawada T, et al. Jpn J Thorac Cardiovasc Surg. 1999 Mar;47(3):104-9.
molnova catalog



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