Arbutin

Research use only, not for human use.

Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.

Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.(In Vitro):Arbutin (0.3-5.4 mM; 24 hours, 48 hours, 72 hours; B16 murine melanoma cells) inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner.Arbutin (1.4-5.4 mM; 24 hours) increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM.(In Vivo):Arbutin (50 mg/kg, 100 mg/kg; oral administration; every day; for 17 days; male C57BL/6 mice) pretreatment exhibits markedly protective effects on ISO-induced cardiac hypertrophy in mice.

Cell Viability Assay Cell Line:B16 murine melanoma cells Concentration:0.3 mM, 0.7 mM, 1.4 mM, 2.1 mM, 2.9 mM, 3.6 mM, 5.4 mM Incubation Time:24 hours, 48 hours or 72 hours Result:Inhibited the viability of B16 murine melanoma cells in a time- and dose-dependent manner.Apoptosis Analysis Cell Line:B16 murine melanoma cells Concentration:1.4 mM, 2.9 mM, 5.4 mM Incubation Time:24 hours Result:Caused apoptosis in 19.3% of the cells.

Animal Model:Male C57BL/6 mice ( 20-25 g)Dosage:50 mg/kg, 100 mg/kg Administration:Oral administration; every day; for 17 days Result:Ameliorated the ISO-induced myocardial injury.

β-Arbutin | NSC 4036

Proteasome/Ubiquitin

Tyrosinase

Tyrosinase

Other Indications

——

497-76-7

272.25

C12H16O7

>98% (HPLC)

Water: 55 mg/mL (202.02 mM); DMSO: 55 mg/mL (202.02 mM)

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(O)C=C2

(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol

(-20℃)

With Ice Pack

≥ 2 years