Apostatin-1( Apt-1 )

Catalog No. M24150 CAS No. 2559703-06-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Apostatin-1
Note

Research use only, not for human use.
Brief Description

Apostatin-1 is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.
Description

Apostatin-1 is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.
In Vitro

Western Blot Analysis Cell Line:SH-SY5Y, HeLa, HT-29, and Jurkat cells Concentration:10 μM Incubation Time:6 h Result:Effectively induced autophagy by LC3 II induction and p62 reduction.
In Vivo

Animal Model:Wild-type mice (n = 10, male, 8 weeks of age, systemic inflammation mouse model)Dosage:20 mg/kgAdministration:IP, onceResult:Reduced expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns, including interferon γ (IFNγ), lipopolysaccharide (LPS), Pam3CSK4 (a synthetic bacterial lipopeptide), and muramyl dipeptide (MDP). Showed increased survival following intravenous delivery of TNF, a mouse model of systemic inflammation.
Synonyms

Apt-1
Pathway

Others
Target

Other Targets
Recptor

TRADD
Research Area

——
Indication

——

CAS Number

2559703-06-7
Formula Weight

345.5
Molecular Formula

C19H27N3OS
Purity

>98% (HPLC)
Solubility

DMSO:65mg/ml(188.13mM; need ultrasonic); Ethanol:9mg/ml(26.06mM; need ultrasonic)
SMILES

O=C(NC1CCCCCC1)C(C2=CC=CC=C2)SC3=NCCN3C
Chemical Name

——

1.Xu D , Zhao H , Jin M , et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis[J]. Nature, 2020, 587(7832):1-6.

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