Amonafide ( AS1413 )

Catalog No. M15655 CAS No. 69408-81-7

A novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	42	Get Quote
5MG	66	Get Quote
10MG	80	Get Quote
25MG	149	Get Quote
50MG	266	Get Quote
100MG	442	Get Quote
200MG	Get Quote	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

Amonafide
Note

Research use only, not for human use.
Brief Description

A novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
Description

A novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.Chemotherapeutic Agents Phase 3 Discontinued
Synonyms

AS1413
Pathway

Cell Cycle/DNA Damage
Target

Topoisomerase
Recptor

TopoII
Research Area

Cancer
Indication

Chemotherapeutic

Chemical Information

CAS Number

69408-81-7
Formula Weight

283.33
Molecular Formula

C16H17N3O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C1N(CCN(C)C)C(C2=CC(N)=CC3=CC=CC1=C23)=O
Chemical Name

1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Allen SL, et al. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003.
2. Zhu H, et al. Mol Cancer Ther. 2007 Feb;6(2):484-95.
3. Liang X, et al. Mol Cancer Res. 2010 Dec;8(12):1619-32.

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