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Home - Products - Cell Cycle/DNA Damage - Topoisomerase - Amonafide

Amonafide

CAS No. 69408-81-7

Amonafide ( AS1413 )

Catalog No. M15655 CAS No. 69408-81-7

A novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 149 Get Quote
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Biological Information

  • Product Name
    Amonafide
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
  • Description
    A novel topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.Chemotherapeutic Agents Phase 3 Discontinued
  • Synonyms
    AS1413
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    TopoII
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    69408-81-7
  • Formula Weight
    283.33
  • Molecular Formula
    C16H17N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1N(CCN(C)C)C(C2=CC(N)=CC3=CC=CC1=C23)=O
  • Chemical Name
    1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Allen SL, et al. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003.
2. Zhu H, et al. Mol Cancer Ther. 2007 Feb;6(2):484-95.
3. Liang X, et al. Mol Cancer Res. 2010 Dec;8(12):1619-32.
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