Cart
sales@molnova.com
Amelubant
CAS No. 346735-24-8
Amelubant( BIIL284 | BIIL-284 )
Catalog No. M14191 CAS No. 346735-24-8
Amelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAmelubant
-
NoteResearch use only, not for human use.
-
Brief DescriptionAmelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist.
-
DescriptionAmelubant (BIIL284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist, inhibits LTB4-induced mouse ear inflammation with ED50 of 0.008 mg/kg (p.o.); inhibits LTB(4)-induced transdermal chemotaxis in guinea pigs with ED50 of 0.03 mg/kg p.o.Rheumatoid Arthritis Phase 2 Discontinued.
-
In VitroAmelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively.
-
In Vivo——
-
SynonymsBIIL284 | BIIL-284
-
PathwayGPCR/G Protein
-
TargetLeukotriene Receptor
-
RecptorLeukotriene Receptor
-
Research AreaInflammation/Immunology
-
IndicationRheumatoid Arthritis
Chemical Information
-
CAS Number346735-24-8
-
Formula Weight538.644
-
Molecular FormulaC33H34N2O5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (185.66 mM)
-
SMILESO=C(OCC)N/C=N/C1=CC=C(OCC2=CC=CC(COC3=CC=C(C(C)(C4=CC=C(O)C=C4)C)C=C3)=C2)C=C1
-
Chemical Nameethyl (Z)-(amino(4-((3-((4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)methyl)benzyl)oxy)phenyl)methylene)carbamate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Birke FW, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.
2. D?ring G, et al. J Cyst Fibros. 2014 Mar;13(2):156-63.
molnova catalog
related products
-
Masilukast
Masilukast(MCC-847) is an oral leukotriene D4 (LTD4) receptor antagonist for the study of diseases associated with inflammation.
-
Ablukast
Ablukast is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic.
-
AS-35
AS-35 is an orally effective, potent, and selective antagonist of leukotrienes, antagonizing LTC4-, LTD4-, and LTE4-induced ileum contractions with IC50 values of 8 nM, 4 nM, and 3 nM, respectively.
