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Home - Products - Cell Cycle/DNA Damage - PARP - Amelparib

Amelparib

CAS No. 1227156-72-0

Amelparib( JPI-289 | JPI289 )

Catalog No. M10874 CAS No. 1227156-72-0

Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Amelparib
  • Note
    Research use only, not for human use.
  • Brief Description
    Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
  • Description
    Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.Stroke Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JPI-289 | JPI289
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    Neurological Disease
  • Indication
    Stroke

Chemical Information

  • CAS Number
    1227156-72-0
  • Formula Weight
    343.427
  • Molecular Formula
    C19H25N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (291.19 mM)
  • SMILES
    O=C1C2=C(NCCC2)C3=C(OCC)C=C(CN4CCOCC4)C=C3N1
  • Chemical Name
    10-ethoxy-8-[(morpholin-4-yl)methyl]-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679. 2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6.
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