Amelparib( JPI-289 | JPI289 )

Catalog No. M10874 CAS No. 1227156-72-0

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Product Name

Amelparib
Note

Research use only, not for human use.
Brief Description

Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
Description

Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.Stroke Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

JPI-289 | JPI289
Pathway

Cell Cycle/DNA Damage
Target

PARP
Recptor

PARP
Research Area

Neurological Disease
Indication

Stroke

CAS Number

1227156-72-0
Formula Weight

343.427
Molecular Formula

C19H25N3O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (291.19 mM)
SMILES

O=C1C2=C(NCCC2)C3=C(OCC)C=C(CN4CCOCC4)C=C3N1
Chemical Name

10-ethoxy-8-[(morpholin-4-yl)methyl]-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one

1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679. 2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6.

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