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Naquotinib
CAS No. 1448232-80-1
Naquotinib ( ASP8273 )
Catalog No. M11913 CAS No. 1448232-80-1
Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 55 | Get Quote |
|
| 5MG | 88 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameNaquotinib
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NoteResearch use only, not for human use.
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Brief DescriptionNaquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
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DescriptionNaquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)); more potently than that of WT EGFR (IC50= 230 nM); shows activity in mutant EGFR cell line which is resistant to other EGFR TKIs including AZD9291 and CO-1686.Lung Cancer Phase 1 Discontinued
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SynonymsASP8273
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1448232-80-1
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Formula Weight562.71
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Molecular FormulaC30H42N8O3
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESCCC1=C(N=C(C(=N1)C(=O)N)NC2=CC=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC5CCN(C5)C(=O)C=C
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Chemical Name2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.
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