Naquotinib ( ASP8273 )

Catalog No. M11913 CAS No. 1448232-80-1

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Product Name

Naquotinib
Note

Research use only, not for human use.
Brief Description

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR.
Description

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)); more potently than that of WT EGFR (IC50= 230 nM); shows activity in mutant EGFR cell line which is resistant to other EGFR TKIs including AZD9291 and CO-1686.Lung Cancer Phase 1 Discontinued
Synonyms

ASP8273
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

Cancer
Indication

Lung Cancer

CAS Number

1448232-80-1
Formula Weight

562.71
Molecular Formula

C30H42N8O3
Purity

>98% (HPLC)
Solubility

DMSO
SMILES

CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC5CCN(C5)C(=O)C=C
Chemical Name

2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-

1. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.

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