
Ailanthone
CAS No. 981-15-7
Ailanthone( Δ13-Dehydrochaparrinone )
Catalog No. M22794 CAS No. 981-15-7
Ailanthone is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69?nM) and constitutively active truncated AR splice variants (IC50: 309?nM).
Purity : >98% (HPLC)






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Biological Information
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Product NameAilanthone
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NoteResearch use only, not for human use.
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Brief DescriptionAilanthone is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69?nM) and constitutively active truncated AR splice variants (IC50: 309?nM).
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DescriptionAilanthone is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69?nM) and constitutively active truncated AR splice variants (IC50: 309?nM).Ailanthone binds to the co-chaperone protein p23 and prevents AR's interaction with HSP90, thus resulting in the disruption of the AR-chaperone complex followed by ubiquitin/proteasome-mediated degradation of AR as well as other p23 clients including AKT and Cdk4, and downregulates AR and its target genes in PCa cell lines and orthotopic animal tumors. In addition, Ailanthone blocks tumor growth and metastasis of CRPC. Ailanthone has been shown to possess a growth-inhibitory effect against several cancer cell lines including R-HepG2, Jurkat, HeLa, HepG2, Hep3B, MCF-7, MDA-MB-231, and A549 cells. Ailanthone inhibits Huh7 cell growth through the induction of mitochondrion-mediated cell apoptosis and G0/G1 cell cycle arrest. Ailanthone-induced apoptosis is mitochondrion-mediated and involved the PI3K/AKT signaling pathway in Huh7 cells.Ailanthone (i.p. or p.o.) has excellent efficiency for blocking the growth of CRPC xenografts. In pharmacokinetic studies, Ailanthone exhibits good solubility in water and good bioavailability (>20%). In addition, Ailanthone effectively suppresses CRPC tumor growth, despite not reaching a steady state of plasma drug concentration during the course of treatment.
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In Vitro——
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In Vivo——
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SynonymsΔ13-Dehydrochaparrinone
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PathwayEndocrinology/Hormones
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TargetAndrogen Receptor (AR)
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RecptorAndrogen Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number981-15-7
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Formula Weight376.4
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Molecular FormulaC20H24O7
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Purity>98% (HPLC)
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SolubilityDMSO:80 mg/mL (212.54 mM; Need warming)
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SMILESC[C@@]1([C@@H]2O)[C@]([C@@]3([C@@H]4O)O)([H])[C@@]([C@](C5)([H])C4=C)(CO3)[C@@](OC5=O)([H])C[C@@]1([H])C(C)=CC2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. He Y, et al. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat Commun. 2016 Dec 13;7:13122.
molnova catalog



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