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Home - Products - Membrane Transporter/Ion Channel - Chloride Channel - Afoxolaner

Afoxolaner

CAS No. 1093861-60-9

Afoxolaner( —— )

Catalog No. M23298 CAS No. 1093861-60-9

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Afoxolaner
  • Note
    Research use only, not for human use.
  • Brief Description
    Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.
  • Description
    Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
  • In Vitro
    ——
  • In Vivo
    A single oral treatment with a dose approaching the minimum effective dose of Afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Chloride Channel
  • Recptor
    Chloride Channel|GABA|Parasite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1093861-60-9
  • Formula Weight
    625.87
  • Molecular Formula
    C26H17ClF9N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 250 mg/mL (399.44 mM)
  • SMILES
    O=C(CNC(c1ccc(C(C2)=NOC2(C(F)(F)F)c2cc(C(F)(F)F)cc(Cl)c2)c2ccccc12)=O)NCC(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol.?2014 Apr 2;201(3-4):223-5.
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