Adrenosterone( Adrenosterone | )

Catalog No. M14326 CAS No. 382-45-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Adrenosterone
Note

Research use only, not for human use.
Brief Description

Adrenosterone is a steroid hormone with weak androgenic effect.
Description

Adrenosterone is a steroid hormone with weak androgenic effect. (In Vitro):Adrenosterone markedly decreases Snail and Slug expression in HCCLM3 and MDA-MB-231 cells. Adrenosterone suppresses cell motility and invasion of highly metastatic human cancer cells (HCCLM3, MDA-MB-231, and MDA-MB-435 cells).Adrenosterone is a competitive inhibitor of HSD11β1, which catalyzes the interconversion of the steroid pair of the inactive metabolite cortisone and the stress hormone cortisol. Adrenosterone decreases the amount of cortisol.
In Vitro

Adrenosterone markedly decreases Snail and Slug expression in HCCLM3 and MDA-MB-231 cells. Adrenosterone suppresses cell motility and invasion of highly metastatic human cancer cells (HCCLM3, MDA-MB-231, and MDA-MB-435 cells). Adrenosterone is a competitive inhibitor of HSD11β1, which catalyzes the interconversion of the steroid pair of the inactive metabolite cortisone and the stress hormone cortisol. Adrenosterone decreases the amount of cortisol.
In Vivo

——
Synonyms

Adrenosterone |
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor
Research Area

Endocrinology
Indication

——

CAS Number

382-45-6
Formula Weight

300.4
Molecular Formula

C19H24O3
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

C[C@@]([C@](CC1)([H])[C@]2([H])CCC3=CC(CC[C@]3(C)[C@@]2([H])C4=O)=O)(C4)C1=O
Chemical Name

(8S,9S,10R,13S,14S)-10,13-dimethyl-6,7,8,9,10,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,11,17(2H)-trione

1.Blasco M, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1509-15.

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