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Acalisib
CAS No. 870281-34-8
Acalisib ( GS-9820;GS9820;GS 9820;CAL-120;CAL120;CAL 120 )
Catalog No. M16322 CAS No. 870281-34-8
Acalisib (GS-9820, CAL-120) is a potent, isoform-selective PI3K p110δ with IC50 of 12.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 71 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 210 | In Stock |
|
| 50MG | 318 | In Stock |
|
| 100MG | 461 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAcalisib
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NoteResearch use only, not for human use.
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Brief DescriptionAcalisib (GS-9820, CAL-120) is a potent, isoform-selective PI3K p110δ with IC50 of 12.7 nM.
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DescriptionAcalisib (GS-9820, CAL-120) is a potent, isoform-selective PI3K p110δ with IC50 of 12.7 nM, displays >100-fold selectivity over P110α/β/γ, and other class II/III PI3Ks, DNA-PK, mTOR; inhibits anti-FCRI PI3Kδ induced CD63 expression with IC50 of 14 nM in human whole blood with IC50 of 14 nM; induces osteoclast retraction in rat osteoclasts, disrupts actin belts and blocks RANKL-stimulated osteoclast survival.Blood Cancer Phase 2 Clinical
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SynonymsGS-9820;GS9820;GS 9820;CAL-120;CAL120;CAL 120
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kδ
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number870281-34-8
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Formula Weight401.40
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Molecular FormulaC21H16FN7O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 29 mg/mL
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SMILESO=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4NC=NC4=NC=N3)C)=NC5=C1C=C(F)C=C5
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Chemical Name4(3H)-Quinazolinone, 6-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shugg RP, et al. J Biol Chem. 2013 Dec 6;288(49):35346-57.
2. Lopez-Guadamillas E, et al. Aging (Albany NY). 2016 Nov 4;8(11):2747-2753.
3. Kater AP, et al. Blood Cancer J. 2018 Feb 12;8(2):16.
2. Lopez-Guadamillas E, et al. Aging (Albany NY). 2016 Nov 4;8(11):2747-2753.
3. Kater AP, et al. Blood Cancer J. 2018 Feb 12;8(2):16.
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