Absinthiin( Absinthin | NSC 407315 | NSC-407315 )

Catalog No. M17973 CAS No. 1362-42-1

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Product Name

Absinthiin
Note

Research use only, not for human use.
Brief Description

Absinthiin is a weak HIV-1 protease inhibitor.
Description

Absinthin is possible treatment candidate for Acute lung injury (ALI). ALI symptoms include severe lung inflammation. Absinthin causes an anti-inflammatory effect by enhancing activity of matrix metalloproteinase-8 (MMP-8), which inhibits grwoth of inflammatory cells.
In Vitro

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In Vivo

Animal Model:LPS-induced acute lung injury in miceDosage:20, 40, 80mg/kg Administration:p.o.Result:Reduced inflammatory cell infiltration and improved lung architecture.Reduced MPO activity, infiltration of neutrophils, lung tissue wet-to-dry ratio.Reduced the secretion of proinflammatory cytokines and chemokines (TNF-α, IL-1β, IL-6, and MIP-1α).
Synonyms

Absinthin | NSC 407315 | NSC-407315
Pathway

Others
Target

Other Targets
Recptor

HIV-1 protease
Research Area

Others-Field
Indication

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