AZD9496
CAS No. 1639042-08-2
AZD9496 ( AZD-9496 )
Catalog No. M12477 CAS No. 1639042-08-2
A potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 64 | In Stock |
|
5MG | 106 | In Stock |
|
10MG | 178 | In Stock |
|
25MG | 333 | In Stock |
|
50MG | 493 | In Stock |
|
100MG | 713 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAZD9496
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
-
DescriptionA potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68; shows pM equipotent binding to both ERα and ERβ isoforms, highly selective binding compared with progesterone (~650-fold), glucocorticoid (~11,223-fold), and androgen (~36,375-fold) receptor LBDs; downregulator of ERα in vitro and in vivo in ER-positive models of breast cancer and orally available. Breast Cancer Phase 1 Clinical
-
SynonymsAZD-9496
-
PathwayEndocrinology/Hormones
-
TargetEstrogen Receptor/ERR
-
RecptorERα
-
Research AreaCancer
-
IndicationBreast Cancer
Chemical Information
-
CAS Number1639042-08-2
-
Formula Weight442.47
-
Molecular FormulaC25H25F3N2O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 104.5 mg/mL
-
SMILESCC1CC2=C(C(N1CC(C)(C)F)C3=C(C=C(C=C3F)C=CC(=O)O)F)NC4=CC=CC=C24
-
Chemical Name2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. De Savi C, et al. J Med Chem. 2015 Oct 22;58(20):8128-40.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.
2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.
molnova catalog
related products
-
GSK-4716
GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand.
-
Megestrol acetate
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general.
-
(Z)-4-Hydroxytamoxif...
A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.