AZD5904 ( AZD 5904;AZD-5904 )

Catalog No. M15342 CAS No. 618913-30-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZD5904
Note

Research use only, not for human use.
Brief Description

AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM.
Description

AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat; displays 10 to 19-fold selective compared to the closely related lactoperoxidase and thyroid peroxidase, >70-fold to a broad panel of other enzymes, ion channels, and receptors; 1 μM AZD5904 inhibited PMA stimulated HOCl by >90% in isolated human neutrophils; a plasma concentration of ~5 μM decreased the in vivo formation of glutathione sulphonamide in rats.Multiple Sclerosis Phase 1 Discontinued
Synonyms

AZD 5904;AZD-5904
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Inflammation/Immunology
Indication

Multiple Sclerosis

CAS Number

618913-30-7
Formula Weight

252.29
Molecular Formula

C10H12N4O2S
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL 495.46 mM
SMILES

O=C1NC(N(C[C@H]2OCCC2)C3=C1NC=N3)=S
Chemical Name

6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- (9CI)