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AZD5904

CAS No. 618913-30-7

AZD5904( AZD 5904 | AZD-5904 )

Catalog No. M15342 CAS No. 618913-30-7

AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 102 Get Quote
10MG 140 Get Quote
25MG 282 Get Quote
50MG 507 Get Quote
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Biological Information

  • Product Name
    AZD5904
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM.
  • Description
    AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat; displays 10 to 19-fold selective compared to the closely related lactoperoxidase and thyroid peroxidase, >70-fold to a broad panel of other enzymes, ion channels, and receptors; 1 μM AZD5904 inhibited PMA stimulated HOCl by >90% in isolated human neutrophils; a plasma concentration of ~5 μM decreased the in vivo formation of glutathione sulphonamide in rats.Multiple Sclerosis Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AZD 5904 | AZD-5904
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Inflammation/Immunology
  • Indication
    Multiple Sclerosis

Chemical Information

  • CAS Number
    618913-30-7
  • Formula Weight
    252.292
  • Molecular Formula
    C10H12N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 125 mg/mL 495.46 mM
  • SMILES
    O=C1NC(N(C[C@H]2OCCC2)C3=C1NC=N3)=S
  • Chemical Name
    6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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