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AZD5423
CAS No. 1034148-04-3
AZD5423( —— )
Catalog No. M23241 CAS No. 1034148-04-3
AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | In Stock |
|
| 5MG | 87 | In Stock |
|
| 10MG | 147 | In Stock |
|
| 25MG | 267 | In Stock |
|
| 50MG | 475 | In Stock |
|
| 100MG | 692 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD5423
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NoteResearch use only, not for human use.
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Brief DescriptionAZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.
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DescriptionAZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.
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In VitroThe affinity of AZD5423 to the glucocorticoid receptor is high with an IC50 of 0.9 nM in a radioligand human glucocorticoid receptor assay, and selectivity towards other steroid hormone receptors is >900-fold.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGlucocorticoid receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1034148-04-3
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Formula Weight487.45
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Molecular FormulaC25H21F4N3O3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (205.15 mM; Need ultrasonic)
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SMILESO=C(N[C@@H](C)[C@H](OC1=CC2=C(N(C3=CC=C(F)C=C3)N=C2)C=C1)C4=CC=CC(OC)=C4)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Werkstr?m V, et al. Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator AZD5423 after Inhalation in Healthy Volunteers. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581.
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