AZD3514 ( AZD3514; AZD 3514; AZD-3514 )

Catalog No. M10970 CAS No. 1240299-33-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

AZD3514
Note

Research use only, not for human use.
Brief Description

AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
Description

AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
Synonyms

AZD3514; AZD 3514; AZD-3514
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor
Research Area

Cancer
Indication

——

CAS Number

1240299-33-5
Formula Weight

519.56
Molecular Formula

CHFNO
Purity

>98%(HPLC)
Solubility

DMSO:93 mg/mL (179 mM);Ethanol:93 mg/mL (179 mM);Water:<1 mg/mL
SMILES

CC(N1CCN(CCOC2=CC=C(C3CCN(C4=NN5C(CC4)=NN=C5C(F)(F)F)CC3)C=C2)CC1)=O
Chemical Name

1-(4-(2-(4-(1-(3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone

1.Sarah A. Loddick, et al. Cancer Res, 2012, 72(8 Suppl), Abstract nr 3848.

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