AZ82

Research use only, not for human use.

AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor.

AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM; effectively engages with the minus end-directed KIFC1 motor inside cells to reverse the monopolar spindle phenotype induced by the inhibition of the plus end-directed kinesin Eg5; causes centrosome declustering in BT-549 breast cancer cells with amplified centrosomes.

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KIFC1 inhibitor AZ82

Cytoskeleton/Cell Adhesion Molecules

Kinesin

Kinesin

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1449578-65-7

560.6

C28H31F3N4O3S

>98% (HPLC)

DMSO : 125 mg/mL 222.96 mM

CCCC1=C(SC(=C1)C(=O)NC(CC2=CN=C(C=C2)C3=CC(=CC=C3)OC(F)(F)F)C(=O)NC4CCNC4)C

5-methyl-N-((R)-1-oxo-1-(((R)-pyrrolidin-3-yl)amino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years