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Home - Products - Membrane Transporter/Ion Channel - Sodium Channel - AZ194

AZ194

CAS No. 2241651-99-8

AZ194( CRMP2-Ubc9-NaV1.7 inhibitor 194 )

Catalog No. M28702 CAS No. 2241651-99-8

CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ194
  • Note
    Research use only, not for human use.
  • Brief Description
    CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.
  • Description
    CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.
  • In Vitro
    ——
  • In Vivo
    AZ194 would provide pain relief in rat models of chemotherapy- and nerve injury- induced neuropathic pain. AZ194 (orally; at 2 and 10 mg/kg) restores mechanical sensitivity in animals with chemotherapy-induced and nerve injury-induced neuropathic nociception.AZ194 (10 mg/kg; ip; CD1 male mice) does not affect motor performance (open field). AZ194 synergizes with commonly used painkillers, engages NaV1.7-dependent endogenous opioid signaling.
  • Synonyms
    CRMP2-Ubc9-NaV1.7 inhibitor 194
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2241651-99-8
  • Formula Weight
    567.637
  • Molecular Formula
    C34H31F2N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (58.72 mM)
  • SMILES
    COc1cc(ccc1OCc1cccc(F)c1)C(=O)N1CCC(CC1)c1nc2ccccc2n1Cc1cccc(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dzierba CD, Hartz RA, Bronson JJ. Recent advances in corticotropin-releasing factor receptor antagonists. Annu Rep Med Chem. 2008;43:3–23.
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