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Home - Products - Membrane Transporter/Ion Channel - Sodium Channel - XEN-907

XEN-907

CAS No. 912656-34-9

XEN-907( XEN907 | XEN 907 )

Catalog No. M16553 CAS No. 912656-34-9

A potent, selective NaV1.7 blocker with IC50 of 3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 214 Get Quote
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Biological Information

  • Product Name
    XEN-907
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective NaV1.7 blocker with IC50 of 3 nM.
  • Description
    A potent, selective NaV1.7 blocker with IC50 of 3 nM; shows no significant activity at 10 uM against a broad panel of 63 receptors and transporters; has no cytotoxic and favourable hepatocyte metabolic stability for both human and dog,Pain Preclinical.
  • In Vitro
    XEN907 is not cytotoxic in HepG2 cells (% viable after 16 h: >99%).XEN907 shows moderate hepatocyte stability (% remaining after 2 h: rat 21%; human 34%; dog 46%) across species.
  • In Vivo
    XEN907 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (13 %), Cmax (35 ng/mL), and AUClast (143 h?ng/mL) in rats.XEN907 (3 mg/kg; i.v.) exhibits terminal elimination half-life (2.6 h), high plasma clearance (9.4 L/h/kg), and large volumes of distribution (35.0 L/kg) in rats.
  • Synonyms
    XEN907 | XEN 907
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    912656-34-9
  • Formula Weight
    351.3958
  • Molecular Formula
    C21H21NO4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C12COC3=C1C=C(OCO4)C4=C3)N(CCCCC)C5=C2C=CC=C5
  • Chemical Name
    Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-pentyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chowdhury S, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3676-81.
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