TASP0382088

CAS No. 1253941-85-3

TASP0382088( TASP-0382088 )

Catalog No. M11022 CAS No. 1253941-85-3

A potent, selective ALK5 inhibitor with IC50 of 4.8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TASP0382088
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective ALK5 inhibitor with IC50 of 4.8 nM.
  • Description
    A potent, selective ALK5 inhibitor with IC50 of 4.8 nM, >100-fold selectivity over 95 different kinases; inhibits TGF-β-induced Smad2/3 phosphorylation at cellular level with IC50 of 17 nM, inhibits Smad2 phosphorylation in mouse skin after topical application.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TASP-0382088
  • Pathway
    TGF-beta/Smad
  • Target
    TGFBR
  • Recptor
    TGFBR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1253941-85-3
  • Formula Weight
    328.408
  • Molecular Formula
    C15H12N4OS2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Amada H, et al. Chem Pharm Bull (Tokyo). 2013;61(3):286-91.
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