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GZ389988
CAS No. 1788906-96-6
GZ389988( GZ-389988 | GZ 389988 )
Catalog No. M12693 CAS No. 1788906-96-6
GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis; shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
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| 50MG | 1782 | Get Quote |
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| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGZ389988
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NoteResearch use only, not for human use.
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Brief DescriptionGZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis; shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R).
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DescriptionGZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis; shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R), GZ389988 is highly selective against a wide panel of other kinases; GZ389988 can significantly reduces local joint pain, without effect on ipsilateral joint pain; GZ389988 also is efficacious in the PGPS arthritis model, demonstrating a significant improvement of gait analysis scores following painful disease reactivation flares.Other Indication Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsGZ-389988 | GZ 389988
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PathwayTyrosine Kinase
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TargetTrk Receptor
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RecptorTrk Receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1788906-96-6
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Formula Weight470.533
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Molecular FormulaC26H26N6O3
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Purity>98% (HPLC)
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Solubility——
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SMILESNC1=NC2=CC(C3=CN(C)N=C3)=CN=C2N1CC4=CC=C(OCC5=CC=C(OC)C=C5)C(OC)=C4
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Chemical Name3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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