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AX-15836
CAS No. 2035509-96-5
AX-15836 ( AX15836 )
Catalog No. M13168 CAS No. 2035509-96-5
A potent, highly selective ERK5 inhibitor with IC50 of 8 nM; shows little affinity for BRD4 (Kd=3.6 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 96 | Get Quote |
|
| 5MG | 168 | Get Quote |
|
| 10MG | 248 | Get Quote |
|
| 25MG | 510 | Get Quote |
|
| 50MG | 732 | Get Quote |
|
| 100MG | 1017 | Get Quote |
|
| 500MG | 2034 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAX-15836
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective ERK5 inhibitor with IC50 of 8 nM; shows little affinity for BRD4 (Kd=3.6 uM).
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DescriptionA potent, highly selective ERK5 inhibitor with IC50 of 8 nM; shows little affinity for BRD4 (Kd=3.6 uM); clearly inhibits the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells.
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SynonymsAX15836
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK
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Research Area——
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Indication——
Chemical Information
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CAS Number2035509-96-5
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Formula Weight648.78
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Molecular FormulaC32H40N8O5S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 101 mg/mL 155.68 mM
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SMILESO=C1C2=CC=CC=C2N(S(=O)(C)=O)C3=NC(NC4=CC=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4OCC)=NC=C3N1C
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Chemical Name6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-11-(methylsulfonyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lin EC, et al. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870.
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