AVN944 ( AVN 944; AVN-944; AVN944; VX944; VX 944; VX-944. )

Catalog No. M13910 CAS No. 297730-17-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AVN944
Note

Research use only, not for human use.
Brief Description

AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
Description

AVN-944(VX-944) is a selective, noncompetitive inhibitor of the enzyme directed against human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
Synonyms

AVN 944; AVN-944; AVN944; VX944; VX 944; VX-944.
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

IMPDH
Research Area

Cancer
Indication

——

CAS Number

297730-17-7
Formula Weight

477.51
Molecular Formula

C25H27N5O5
Purity

>98%(HPLC)
Solubility

DMSO: 58 mg/mL
SMILES

O=C(O[C@H](CC)CC#N)N[C@H](C1=CC=CC(NC(NC2=CC=C(C3=CN=CO3)C(OC)=C2)=O)=C1)C
Chemical Name

(R)-1-cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate

1.Zimmermann AG, et al. Prog Nucleic Acid Res Mol Biol. 1998;61:181-209.

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