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AVN-101
CAS No. 1025725-91-0
AVN-101( AVN101 )
Catalog No. M10121 CAS No. 1025725-91-0
A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki?=?1.2-2.0 ?nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAVN-101
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NoteResearch use only, not for human use.
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Brief DescriptionA higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki?=?1.2-2.0 ?nM).
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DescriptionA higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki?=?1.2-2.0 ?nM); also exhibits a rather high affinity toward histamine H1 (Ki?=?0.58?nM) and adrenergic α2A, α2B, and α2C (Ki?=?0.41-3.6?nM) receptors; demonstrates reasonable anxiolytic and anti-depressive activities in animal models of CNS diseases with low safety concerns.Anxiety Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAVN101
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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IndicationAnxiety
Chemical Information
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CAS Number1025725-91-0
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Formula Weight304.437
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Molecular FormulaC21H24N2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4
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Chemical Name2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ivachtchenko AV, et al. J Alzheimers Dis. 2016 May 25;53(2):583-620.
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