
AUTEN-99
CAS No. 904054-02-0
AUTEN-99( —— )
Catalog No. M16499 CAS No. 904054-02-0
A small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy.
Purity : >98% (HPLC)






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Biological Information
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Product NameAUTEN-99
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy.
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DescriptionA small molecule autophagy enhancer that inhibit the myotubularin-related phosphatase MTMR14/Jumpy; induces autophagic flux and promotes cell survival in mammalian cell cultures; increases the number of autophagic structures in mice and Drosophila, and effectively penetrates through a blood-brain barrier model; impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson's and Huntington's diseases.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number904054-02-0
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Formula Weight278.373
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Molecular FormulaC17H14N2S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-([1,1'-biphenyl]-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference



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LC3-mHTT-IN-AN1
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.
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PD146176
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
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Fluorescein Biotin
Fluorescein Biotin is a biotin-substituting fluorescent dye that detects and quantifies biotin binding sites by fluorescence or absorbance.Fluorescein Biotin undergoes fluorescence quenching when bound to avidin or streptavidin.