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ATC 0175 hydrochloride
CAS No. 510733-97-8
ATC 0175 hydrochloride( —— )
Catalog No. M33831 CAS No. 510733-97-8
ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 109 | Get Quote |
|
| 5MG | 155 | Get Quote |
|
| 10MG | 250 | Get Quote |
|
| 25MG | 495 | Get Quote |
|
| 50MG | 840 | Get Quote |
|
| 100MG | 1341 | Get Quote |
|
| 500MG | 2691 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameATC 0175 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective.
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DescriptionATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.
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In VitroATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively.
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In VivoATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential.
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Synonyms——
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor | GPR | Melanin-concentrating Hormone Receptor (MCHR)
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Research Area——
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Indication——
Chemical Information
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CAS Number510733-97-8
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Formula Weight461.93
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Molecular FormulaC23H26ClF2N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (27.06 mM; Ultrasonic (<60°C)
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SMILESN(C)(C)C=1C2=C(N=C(N[C@H]3CC[C@@H](NC(=O)C4=CC(F)=C(F)C=C4)CC3)N1)C=CC=C2.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11(4):341-52.?
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