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AT101
CAS No. 90141-22-3
AT101 ( —— )
Catalog No. M16483 CAS No. 90141-22-3
AT-101 is the levorotatory isomer of a natural product Gossypol.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameAT101
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NoteResearch use only, not for human use.
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Brief DescriptionAT-101 is the levorotatory isomer of a natural product Gossypol.
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DescriptionAT-101 is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
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Synonyms——
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PathwayAngiogenesis
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TargetBcl-2
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RecptorMcl-1;Bcl-2;Bcl-xL
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number90141-22-3
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Formula Weight518.55
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Molecular FormulaCHO
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Purity>98%(HPLC)
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SolubilityN/A
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SMILESOC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O.[R]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.
2. Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.
2. Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.
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