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Pyridoclax
CAS No. 1651890-44-6
Pyridoclax ( MR-29072 )
Catalog No. M12523 CAS No. 1651890-44-6
Pyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePyridoclax
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NoteResearch use only, not for human use.
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Brief DescriptionPyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction.
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DescriptionPyridoclax (MR29072) is a highly potent Mcl-1 inhibitor with Kd of 25 nM, disrupts Mcl-1/Bim interaction; strongly sensitizes ovarian cancer chemoresistant IGROV1-R10 cells to Bcl-xL targeting siRNA and ABT-737, leading to massive apoptosis, can not induce cell death as single agents; induces ER stress and modifies Bcl-2 family expression, but its cytotoxic effect does not require these events.
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SynonymsMR-29072
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1651890-44-6
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Formula Weight426.51
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Molecular FormulaC29H22N4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=CC(C2=NC=C(C3=CC=CN=C3)C=C2/C=C/C4=CC=CC=C4)=CN=C1C5=CC=CN=C5
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Chemical Name(E)-3'-methyl-3''-styryl-3,2':5',2'':5'',3'''-quaterpyridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gloaguen C, et al. J Med Chem. 2015 Feb 26;58(4):1644-68.
2. Groo AC, et al. Eur J Pharm Sci. 2017 Jan 15;97:218-226.
2. Groo AC, et al. Eur J Pharm Sci. 2017 Jan 15;97:218-226.
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