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AS057278
CAS No. 402-61-9
AS057278( 3-Methylpyrazole-5-carboxylic acid )
Catalog No. M20843 CAS No. 402-61-9
AS057278 is an D-amino acid oxidase (DAAO) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 102 | In Stock |
|
| 25MG | 169 | In Stock |
|
| 50MG | 255 | In Stock |
|
| 100MG | 380 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAS057278
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NoteResearch use only, not for human use.
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Brief DescriptionAS057278 is an D-amino acid oxidase (DAAO) inhibitor.
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DescriptionAS057278 is an D-amino acid oxidase (DAAO) inhibitor.
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In Vitro——
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In VivoAS057278 (PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage) normalizes?phencyclidine?(PCP)-induced?prepulse inhibition.AS057278 (10 mg/kg; PO and IV; single dosage) exhibits good pharmacokinetic effects.Pharmacokinetic Parameters of AS057278 in male Sprague-Dawley rats. Animal Model:Males C57BL/6J miceDosage:80 mg/kg, 20 mg/kg Administration:PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage Result:Normalized?phencyclidine?(PCP)-induced?prepulse inhibition?after acute (80?mg/kg) and chronic (20?mg/kg b.i.d.)?oral administration?in mice.Animal Model:Male Sprague-Dawley ratsDosage:10 mg/kg Administration:PO and IV; single dosage (Pharmacokinetics Analysis)Result:Exhibited good pharmacokinetic effect.
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Synonyms3-Methylpyrazole-5-carboxylic acid
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PathwayOthers
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TargetOther Targets
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RecptorD-amino acid oxidase (DAAO)
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Research Area——
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Indication——
Chemical Information
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CAS Number402-61-9
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Formula Weight126.11
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Molecular FormulaC5H6N2O2
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Purity>98% (HPLC)
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SolubilityDMSO:25mg/mL(198.24mM)
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SMILESCc1cc(C(=O)O)n[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Adage T Anne-Cécile Trillat Quattropani A et al. In vitro and in vivo pharmacological profile of AS057278 a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties[J]. European Neuropsychopharmacology the Journal of the European College of Neuropsychopharmacology 2008 18(3):200-214.
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