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AS-85
CAS No. 2323623-80-7
AS-85( —— )
Catalog No. M35164 CAS No. 2323623-80-7
AS-85, a potent inhibitor of ASH1L histone methyltransferase (IC50 = 0.6 μM), exhibits anti-leukemic activity by strongly binding to the ASH1L SET domain (Kd = 0.78 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 211 | Get Quote |
|
| 5MG | 392 | Get Quote |
|
| 10MG | 655 | Get Quote |
|
| 25MG | 1371 | Get Quote |
|
| 50MG | 2190 | Get Quote |
|
| 100MG | 3411 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAS-85
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NoteResearch use only, not for human use.
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Brief DescriptionAS-85, a potent inhibitor of ASH1L histone methyltransferase (IC50 = 0.6 μM), exhibits anti-leukemic activity by strongly binding to the ASH1L SET domain (Kd = 0.78 μM).
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DescriptionAS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78?μM.
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In VitroAS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI50 values ranging from 5?μM to 25?μM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2323623-80-7
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Formula Weight579.66
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Molecular FormulaC26H28F3N5O3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (172.51 mM; Ultrasonic )
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SMILESNC(=S)c1cccc(c1)-c1cn(C2CCN(CC2)S(=O)(=O)C(F)(F)F)c2cc(CNC(=O)C3CNC3)ccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. David S. Rogawski, Jing Deng, Hao Li, Tomasz Cierpicki, Jolanta Grembecka, et al. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 May 14;12(1):2792.?
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