AS-604850 ( AS604850; AS 604850; AS-604850 )

Catalog No. M17562 CAS No. 648449-76-7

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Product Name

AS-604850
Note

Research use only, not for human use.
Brief Description

AS-604850 is a specific and ATP-competitive PI3Kγ inhibitor (IC50: 250 nM), 18-fold more selective for PI3Kγ than PI3Kα, and over 80-fold selectivity for PI3Kγ than PI3Kδ/β.
Description

AS-604850 is a selective PI3Kγ inhibitor, which significantly reduced the number of infiltrated leukocytes in the CNS and ameliorated the clinical symptoms of EAE mice. Treatment with this PI3Kγ inhibitor enhanced myelination and axon number in the spinal cord of EAE mice. PI3Kγ contributes to development of autoimmune CNS inflammation and that PI3Kγ blockade may provide a great potential for treating patients with MS.
Synonyms

AS604850; AS 604850; AS-604850
Pathway

Others
Target

Other Targets
Recptor

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Research Area

Inflammation/Immunology
Indication

——

CAS Number

648449-76-7
Formula Weight

285.22
Molecular Formula

C11H5F2NO4S
Purity

98%
Solubility

——
SMILES

c1cc2c(cc1/C=C\1/C(=O)NC(=O)S1)OC(O2)(F)F
Chemical Name

(Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione

1. Camps M, et al, Nat Med, 2005, 11(9), 936-943.

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