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ARRY380

CAS No. 937265-83-3

ARRY380 ( ARRY-380 analog; ONT380 analog; ONT 380 analog; ONT-380 analog )

Catalog No. M16714 CAS No. 937265-83-3

ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 105 In Stock
10MG 168 In Stock
25MG 284 In Stock
50MG 422 In Stock
100MG 618 In Stock
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Biological Information

  • Product Name
    ARRY380
  • Note
    Research use only, not for human use.
  • Brief Description
    ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM.
  • Description
    ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.
  • Synonyms
    ARRY-380 analog; ONT380 analog; ONT 380 analog; ONT-380 analog
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR; HER2; p95-HER2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    937265-83-3
  • Formula Weight
    569.63
  • Molecular Formula
    C29H27N7O4S
  • Purity
    >98%(HPLC)
  • Solubility
    DMSO: > 10mM
  • SMILES
    CC1=C(OC2=CC3=NC=NN3C=C2)C=CC(NC2=NC=NC3=C2C=C(C=C3)C2=CC=C(CNCCS(C)(=O)=O)O2)=C1
  • Chemical Name
    6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Madala SK, et al. Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8.
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