ARRY380

CAS No. 937265-83-3

ARRY380 ( ARRY-380 analog; ONT380 analog; ONT 380 analog; ONT-380 analog )

Catalog No. M16714 CAS No. 937265-83-3

ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 63 In Stock
5MG 105 In Stock
10MG 168 In Stock
25MG 284 In Stock
50MG 422 In Stock
100MG 618 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    ARRY380
  • Note
    Research use only, not for human use.
  • Brief Description
    ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM.
  • Description
    ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.
  • Synonyms
    ARRY-380 analog; ONT380 analog; ONT 380 analog; ONT-380 analog
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR; HER2; p95-HER2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    937265-83-3
  • Formula Weight
    569.63
  • Molecular Formula
    C29H27N7O4S
  • Purity
    >98%(HPLC)
  • Solubility
    DMSO: > 10mM
  • SMILES
    CC1=C(OC2=CC3=NC=NN3C=C2)C=CC(NC2=NC=NC3=C2C=C(C=C3)C2=CC=C(CNCCS(C)(=O)=O)O2)=C1
  • Chemical Name
    6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Madala SK, et al. Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8.
molnova catalog
related products
  • PF-06747775

    A potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.

  • Nimotuzumab

    Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).

  • Matuzumab

    Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR frequently associated with the growth of blood vessels in malignancy facilitating tumor growth and survival.