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AR-C102222

CAS No. 253771-21-0

AR-C102222( AR-C 102222 )

Catalog No. M13757 CAS No. 253771-21-0

AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively; reduces inflammation produced by the application of arachidonic acid to the ear, attenuates FCA-induced mechanical hyperalgesia, and attenuates acetic acid-induced writhing in mice.Rheumatoid ArthritisDiscontinued

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    AR-C102222
  • Note
    Research use only, not for human use.
  • Brief Description
    AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively; reduces inflammation produced by the application of arachidonic acid to the ear, attenuates FCA-induced mechanical hyperalgesia, and attenuates acetic acid-induced writhing in mice.Rheumatoid ArthritisDiscontinued
  • Description
    AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively; reduces inflammation produced by the application of arachidonic acid to the ear, attenuates FCA-induced mechanical hyperalgesia, and attenuates acetic acid-induced writhing in mice.Rheumatoid Arthritis Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AR-C 102222
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    NOS
  • Research Area
    Inflammation/Immunology
  • Indication
    Rheumatoid Arthritis

Chemical Information

  • CAS Number
    253771-21-0
  • Formula Weight
    382.375
  • Molecular Formula
    C19H16F2N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CN(CCC12NC3=C(C=CC(=C3C(=N2)N)F)F)C(=O)C4=CN=C(C=C4)C#N.Cl
  • Chemical Name
    Spiro[piperidine-4,2'(1'H)-quinazolin]-4'-amine, 1-[(6-cyano-3-pyridinyl)carbonyl]-5',8'-difluoro- (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Garcin ED, et al. Nat Chem Biol. 2008 Nov;4(11):700-7. 2. Tinker AC, et al. J Med Chem. 2003 Mar 13;46(6):913-6. 3. LaBuda CJ, et al. Eur J Pain. 2006 Aug;10(6):505-12.
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