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APY29
CAS No. 1216665-49-4
APY29( APY29 | APY-29 | APY 29 )
Catalog No. M17198 CAS No. 1216665-49-4
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 53 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 167 | In Stock |
|
| 50MG | 285 | In Stock |
|
| 100MG | 515 | In Stock |
|
| 500MG | 1071 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAPY29
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NoteResearch use only, not for human use.
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Brief DescriptionAPY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
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DescriptionAPY29 is a IRE1α inhibitor. The accumulation of unfolded proteins under endoplasmic reticulum (ER) stress leads to the activation of the multidomain protein sensor IRE1α as part of the unfolded protein response (UPR). ATP-competitive inhibitors of IRE1α promote dimerization and activation of RNase activity despite blocking kinase autophosphorylation.
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In VitroAPY29 divergently modulates the RNase activity and oligomerization state of IRE1α. APY29 is exerting their opposing effects on RNase activity through the same binding site. APY29 divergently affects IRE1α oligomerization. APY29 demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α.
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In Vivo——
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SynonymsAPY29 | APY-29 | APY 29
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PathwayNeuroscience
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TargetP2 Receptor
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RecptorIRE1α
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1216665-49-4
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Formula Weight332.36
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Molecular FormulaC17H16N8
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Purity>98% (HPLC)
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SolubilityDMSO : 10 mg/mL. 30.09 mM;
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SMILESC1CC1c1cc(n[nH]1)Nc1nc(ncc1)Nc1cc2c(cc1)nc[nH]2
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Chemical Name(E)-N-(6-((5-cyclopropyl-1H-pyrazol-3-yl)imino)-1,6-dihydropyrimidin-2-yl)-1H-benzo[d]imidazol-6-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang L, et al. Nat Chem Biol. 2012 Dec;8(12):982-9.
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