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A-317491

CAS No. 475205-49-3

A-317491( ABT 202 )

Catalog No. M24424 CAS No. 475205-49-3

A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A-317491
  • Note
    Research use only, not for human use.
  • Brief Description
    A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
  • Description
    A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male adult Sprague-Dawley rats received an intraplantar injection of Freund's complete adjuvant Dosage:0.1, 1, 3, 10, 30 mg/kg Administration:A single s.c.Result:Produced a dose-dependent reduction in mechanical hyperalgesia 1 h, 3 h and 5 h post-administration.
  • Synonyms
    ABT 202
  • Pathway
    Neuroscience
  • Target
    P2 Receptor
  • Recptor
    Human P2X3|P2X2|P2X3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    475205-49-3
  • Formula Weight
    565.57
  • Molecular Formula
    C33H27NO8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 47 mg/mL (83.10 mM); H2O : < 0.1 mg/mL (insoluble)
  • SMILES
    O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jarvis MF,et al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84.
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