API-1 ( NSC177223 )

Catalog No. M24326 CAS No. 36707-00-3

API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

API-1
Note

Research use only, not for human use.
Brief Description

API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
Description

API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
Synonyms

NSC177223
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

Akt
Research Area

——
Indication

——

Chemical Information

CAS Number

36707-00-3
Formula Weight

337.3
Molecular Formula

C13H15N5O6
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

C1=C(C(=O)C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C(=O)N
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Ren H , Koo J , Guan B , et al. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis[J]. Molecular Cancer, 2013, 12(1):146-146.

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