AP20187

Research use only, not for human use.

AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins. And it initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.

AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins. And it initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.(In Vitro):When LNCaP cells are treated with AP20187 (B/B Homodimerizer) (100 nM), ro-iCaspase-9 levels are significantly reduced. However the smaller processed active caspase-9 becomes apparent.(In Vivo):AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice. AP20187 (B/B Homodimerizer) treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mice. Real-time PCR analysis shows that AP20187 (B/B Homodimerizer) (0.5 mg/kg, 2 mg/kg, or 5 mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mice at PID12.

B/B Homodimerizer

Others

Other Targets

Angiotensin Receptor; NO

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195514-80-8

1482.8

C82H107N5O20

>98% (HPLC)

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CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(=O)NCC(CNC(=O)COc2cccc(c2)[C@@H](CCc2ccc(OC)c(OC)c2)OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](CC)c2cc(OC)c(OC)c(OC)c2)CN(C)C)c1)c1cc(OC)c(OC)c(OC)c1

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(-20℃)

With Ice Pack

≥ 2 years