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ANT431

CAS No. 1639972-90-9

ANT431( ANT 431 | ANT-431 )

Catalog No. M12483 CAS No. 1639972-90-9

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ANT431
  • Note
    Research use only, not for human use.
  • Brief Description
    ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.
  • Description
    ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively); potentiate the activity of meropenem (MEM) against a broad range of MBL-producing carbapenem-resistant Enterobacteriaceae (CRE), restore its efficacy against an Escherichia coli NDM-1 strain in a murine thigh infection model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ANT 431 | ANT-431
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1639972-90-9
  • Formula Weight
    285.292
  • Molecular Formula
    C9H7N3O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC(=CN=C1)S(=O)(=O)NC2=C(N=CS2)C(=O)O
  • Chemical Name
    5-(pyridine-3-sulfonamido)thiazole-4-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Everett M, et al. Antimicrob Agents Chemother. 2018 Mar 12. pii: AAC.00074-18.
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