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ANO1-IN-1

CAS No. 407587-01-3

ANO1-IN-1( —— )

Catalog No. M35506 CAS No. 407587-01-3

ANO1-IN-1, a selective ANO1 channel blocker, inhibited ANO1 and ANO2 with IC50 values of 2.56 μM and 15.43 μM, respectively.ANO1-IN-1 had a significant inhibitory effect on the proliferation of glioma cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ANO1-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    ANO1-IN-1, a selective ANO1 channel blocker, inhibited ANO1 and ANO2 with IC50 values of 2.56 μM and 15.43 μM, respectively.ANO1-IN-1 had a significant inhibitory effect on the proliferation of glioma cells.
  • Description
    ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells.
  • In Vitro
    ANO1-IN-1 (Compound 9c) (10 μM) significantly suppresses migration and invasion of U251 cells.ANO1-IN-1 and TMZ combination brings about remarkable synergistic effects in suppressing proliferation of GBM cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    CRAC Channel
  • Recptor
    Chloride channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    407587-01-3
  • Formula Weight
    336.49
  • Molecular Formula
    C18H28N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (742.96 mM; Ultrasonic )
  • SMILES
    C(N)(=O)C=1C2=C(SC1NC(C(C)(C)C)=O)CC(C(C)(C)C)CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688. ?
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