AN-2728

CAS No. 906673-24-3

AN-2728 ( Crisaborole;AN2728;AN 2728 )

Catalog No. M16514 CAS No. 906673-24-3

A potent PDE4 inhibitor with IC50 of 0.49 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 34 In Stock
50MG 45 In Stock
100MG 75 In Stock
200MG 100 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    AN-2728
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent PDE4 inhibitor with IC50 of 0.49 uM.
  • Description
    A potent PDE4 inhibitor with IC50 of 0.49 uM; also shows inhibition against PDE1A3, PDE3Cat, and PDE7A1; suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.Dermatitis Phase 2 Clinical
  • Synonyms
    Crisaborole;AN2728;AN 2728
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE4
  • Research Area
    Inflammation/Immunology
  • Indication
    Dermatitis

Chemical Information

  • CAS Number
    906673-24-3
  • Formula Weight
    251.05
  • Molecular Formula
    C14H10BNO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 32 mg/mL
  • SMILES
    N#CC1=CC=C(OC2=CC=C3C(B(O)OC3)=C2)C=C1
  • Chemical Name
    Benzonitrile, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Akama T, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32.
2. Nazarian R, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.
3. Freund YR, et al. FEBS Lett. 2012 Sep 21;586(19):3410-4.
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