AN-2728 ( Crisaborole;AN2728;AN 2728 )

Catalog No. M16514 CAS No. 906673-24-3

A potent PDE4 inhibitor with IC50 of 0.49 uM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	34	In Stock
50MG	45	In Stock
100MG	75	In Stock
200MG	100	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

AN-2728
Note

Research use only, not for human use.
Brief Description

A potent PDE4 inhibitor with IC50 of 0.49 uM.
Description

A potent PDE4 inhibitor with IC50 of 0.49 uM; also shows inhibition against PDE1A3, PDE3Cat, and PDE7A1; suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.Dermatitis Phase 2 Clinical
Synonyms

Crisaborole;AN2728;AN 2728
Pathway

Angiogenesis
Target

PDE
Recptor

PDE4
Research Area

Inflammation/Immunology
Indication

Dermatitis

Chemical Information

CAS Number

906673-24-3
Formula Weight

251.05
Molecular Formula

C14H10BNO3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

N#CC1=CC=C(OC2=CC=C3C(B(O)OC3)=C2)C=C1
Chemical Name

Benzonitrile, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Akama T, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32.
2. Nazarian R, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.
3. Freund YR, et al. FEBS Lett. 2012 Sep 21;586(19):3410-4.

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