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AN-2728
CAS No. 906673-24-3
AN-2728 ( Crisaborole;AN2728;AN 2728 )
Catalog No. M16514 CAS No. 906673-24-3
A potent PDE4 inhibitor with IC50 of 0.49 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 34 | In Stock |
|
| 50MG | 45 | In Stock |
|
| 100MG | 75 | In Stock |
|
| 200MG | 100 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAN-2728
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NoteResearch use only, not for human use.
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Brief DescriptionA potent PDE4 inhibitor with IC50 of 0.49 uM.
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DescriptionA potent PDE4 inhibitor with IC50 of 0.49 uM; also shows inhibition against PDE1A3, PDE3Cat, and PDE7A1; suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.Dermatitis Phase 2 Clinical
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SynonymsCrisaborole;AN2728;AN 2728
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE4
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Research AreaInflammation/Immunology
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IndicationDermatitis
Chemical Information
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CAS Number906673-24-3
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Formula Weight251.05
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Molecular FormulaC14H10BNO3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESN#CC1=CC=C(OC2=CC=C3C(B(O)OC3)=C2)C=C1
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Chemical NameBenzonitrile, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Akama T, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32.
2. Nazarian R, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.
3. Freund YR, et al. FEBS Lett. 2012 Sep 21;586(19):3410-4.
2. Nazarian R, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.
3. Freund YR, et al. FEBS Lett. 2012 Sep 21;586(19):3410-4.
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