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AMG-0347

CAS No. 946615-43-6

AMG-0347( —— )

Catalog No. M34498 CAS No. 946615-43-6

AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental stimuli. AMG-0347 acts by blocking the function of TRPA1 and has analgesic effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 603 Get Quote
5MG 922 Get Quote
10MG 1226 Get Quote
25MG 1794 Get Quote
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Biological Information

  • Product Name
    AMG-0347
  • Note
    Research use only, not for human use.
  • Brief Description
    AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental stimuli. AMG-0347 acts by blocking the function of TRPA1 and has analgesic effects.
  • Description
    AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    946615-43-6
  • Formula Weight
    445.48
  • Molecular Formula
    C24H26F3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(=C/C(NC1=C2C(=CC=C1)CCC(O)C2)=O)\C3=C(N=C(C(F)(F)F)C=C3)N4CCCCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chaoran Wu, et al. Effect of AMG0347, a Transient Receptor Potential Type V1 Receptor Antagonist, and Morphine on Pain Behavior after Plantar Incision。Anesthesiology. 2008 Jun;108(6):1100-8.?
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