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AICAR

CAS No. 2627-69-2

AICAR ( Acadesine;AICA Riboside )

Catalog No. M13802 CAS No. 2627-69-2

AICAR (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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50MG 38 In Stock
100MG 59 In Stock
200MG 88 In Stock
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Biological Information

  • Product Name
    AICAR
  • Note
    Research use only, not for human use.
  • Brief Description
    AICAR (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes.
  • Description
    AICAR (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes; inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes at 0.5 mM, inhibits insulin-stimulated glucose and reduces GLUT4 translocation in 3T3-L1 adipocytes; down-regulates the insulin receptor expression in HepG2 cells.
  • Synonyms
    Acadesine;AICA Riboside
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    AMPK
  • Recptor
    AMPK
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    2627-69-2
  • Formula Weight
    258.20
  • Molecular Formula
    C9H14N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    O=C(C1=C(N)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=N1)N
  • Chemical Name
    1H-Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sullivan JE, et al. FEBS Lett. 1994 Oct 10;353(1):33-6.
2. Young ME, et al. FEBS Lett. 1996 Mar 11;382(1-2):43-7.
3. Samari HR, et al. J Biol Chem. 1998 Sep 11;273(37):23758-63.
4. Ayasolla KR, et al. J Neuroinflammation. 2005 Sep 20;2:21.
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