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AKS1-IN-19
CAS No. 2089638-10-6
AKS1-IN-19( AKS1 inhibitor 19 )
Catalog No. M13272 CAS No. 2089638-10-6
A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAKS1-IN-19
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3.
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DescriptionA novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3; displays good kinase selectivity with only 32 kinases having less than 30 fold selectivity in a panel of 356 kinases; inhibits phospho-JNK with pEC50 of 8.2 in cellular assays; displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.
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In Vitro——
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In Vivo——
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SynonymsAKS1 inhibitor 19
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMEK
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Research Area——
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Indication——
Chemical Information
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CAS Number2089638-10-6
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Formula Weight393.447
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Molecular FormulaC21H23N5O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)OC1=CC2=C(CN(C2=O)C3=CC=CC(=N3)C4=NN=CN4C(C)CO)C=C1
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Chemical Name(R)-2-(6-(4-(1-hydroxypropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-6-isopropoxyisoindolin-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lanier M, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320.
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