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Vacquinol-1
CAS No. 5428-80-8
Vacquinol-1( NSC 13316 )
Catalog No. M14945 CAS No. 5428-80-8
Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 387 | In Stock |
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| 10MG | 572 | In Stock |
|
| 25MG | 888 | In Stock |
|
| 50MG | 1224 | In Stock |
|
| 100MG | 1647 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameVacquinol-1
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NoteResearch use only, not for human use.
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Brief DescriptionVacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts.
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DescriptionVacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells; induces rapid and specific cell death of glioma cells via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture; shows good brain penetrance and excellent pharmacokinetics; orally bioactive.
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In Vitro——
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In Vivo——
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SynonymsNSC 13316
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PathwayMAPK/ERK Signaling
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TargetMEK
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RecptorMKK4
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Research Area——
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Indication——
Chemical Information
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CAS Number5428-80-8
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Formula Weight352.862
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Molecular FormulaC21H21ClN2O
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Purity>98% (HPLC)
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SolubilityEthanol: <1 mg/mL; DMSO: 70 mg/mL (164.4 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESClC1=CC=C(C2=NC(C=CC=C3)=C3C(C(O)C4NCCCC4)=C2)C=C1
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Chemical Name[2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kitambi SS, et al. Cell. 2014 Apr 10;157(2):313-28.
2. Hammarstr?m LG, et al. J Med Chem. 2016 Sep 22;59(18):8577-92.
3. Sander P, et al. Oncotarget. 2017 May 23;8(21):35124-35137.
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