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AKR1C1-IN-1

CAS No. 4906-68-7

AKR1C1-IN-1( —— )

Catalog No. M22361 CAS No. 4906-68-7

AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AKR1C1-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).
  • Description
    AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).
  • In Vitro
    AKR1C1-IN-1 potently inhibits the metabolism of progesterone in AKR1C1-overexpressed BAECs, and with an IC50 of 460 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    AKR1C1|AKR1C2|AKR1C3|AKR1C4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4906-68-7
  • Formula Weight
    293.12
  • Molecular Formula
    C13H9BrO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (341.17 mM)
  • SMILES
    O=C(C1=CC(C2=CC=CC=C2)=CC(Br)=C1O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64.
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