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AK306
CAS No.
AK306 ( AK 306;AK-306 )
Catalog No. M16971 CAS No.
AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAK306
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NoteResearch use only, not for human use.
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Brief DescriptionAK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
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DescriptionAK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM; demonstrates broad spectrum activity against of cancer cell lines with total growth inhibition values ranging from ~25 nM to 25 uM; disrupts Aurora A localization, leading to the formation of multiple foci, induces a p53-dependent cell death, and centrosome disruption.
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SynonymsAK 306;AK-306
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PathwayOthers
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TargetClathrin
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RecptorClathrin
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight379.28
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Molecular FormulaC19H20Cl2N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(4-(3,5-dichlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bond MJ, et al. Mol Cancer Res. 2018 May 16. pii: molcanres.0178.2018.
molnova catalog
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AK306
AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
