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AK306

CAS No. ——

AK306( AK 306 | AK-306 )

Catalog No. M16971 CAS No. ——

AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AK306
  • Note
    Research use only, not for human use.
  • Brief Description
    AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
  • Description
    AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM; demonstrates broad spectrum activity against of cancer cell lines with total growth inhibition values ranging from ~25 nM to 25 uM; disrupts Aurora A localization, leading to the formation of multiple foci, induces a p53-dependent cell death, and centrosome disruption.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AK 306 | AK-306
  • Pathway
    Others
  • Target
    Clathrin
  • Recptor
    Clathrin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    379.281
  • Molecular Formula
    C19H20Cl2N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (4-(3,5-dichlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bond MJ, et al. Mol Cancer Res. 2018 May 16. pii: molcanres.0178.2018.
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